Epigenetics and Cancer Therapy
نویسنده
چکیده
Epigenetic approach in treating different diseases has gained importance as the inhibition of the enzymes involved in epigenetic modifications can reverse the disease condition. The major epigenetic markers include DNA methylation, histone acetylation and methylation that alter chromatin structure resulting in changes in cellular functions. The DNA methylation and histone modifications in cancer cells are thought to be important in tumorigenesis and the epigenome modifying enzymes are considered as epigenetic targets in cancer drug discovery. This review will discuss about different epigenetic dysregulations in tumors as well as epigenetic targets for drug discovery and development of novel cancer agents. This article also highlights the recent success in identifying new epigenetic targets and cancer epigenetic drug discovery.
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